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The road map sets global targets and milestones to prevent, control, eliminate or eradicate 20 diseases and disease groups as well as cross-cutting targets aligned with the Sustainable Development Goals. Three foundational pillars will support global efforts to achieve the targets: accelerate programmatic action (pillar 1), intensify cross-cutting approaches (pillar 2) and change operating models and culture to facilitate country ownership (pillar 3).

The disease summaries annexed to the road map detail the current epidemiological status and burden of disease, core strategic interventions and progress towards the 2020 targets of the previous road map. The targets, sub-targets and milestones for 2030, and the critical actions required to achieve them, were used to generate the evidence in the road map document endorsed by the World Health AssemblY