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This handbook aims to further increase awareness of HIV and AIDS for people with disabilities, to share knowledge and to provide examples of best practices. It also examines the impact of the AIDS epidemic on people with disabilities and advocates inclusion of people with disabilities to HIV prevention, treatment, care and support. The handbook is divided into four chapters, each addressing a specific topic in reference to best practices for Disability and HIV and AIDS. Case studies are provided for each topic. The categories of disabilities covered in the handbook are the deaf, visually impaired, physically and intellectually challenged. This handbook is useful for organisations, policy makers, disabled people's organisations and donors interested in Disability and HIV and AIDS